| Clarithromycin xl 500mg
Hypersensitivity to clarithromycin or other ingredients;
The first trimester of pregnancy;
Lactation;
Porphyry;
Simultaneous administration of clarithromycin with the following medicines: astemizole, cisapride, pimozide, terfenadine, ergotamine, dihydroergotamine (see Interactions with other drugs.);
Children under 12 years or with a body weight less than 40 kg (for a given dosage form).
Be wary appoint patients with impaired liver and kidney function.
Pregnancy and lactation
Clarithromycin is contraindicated in the first trimester of pregnancy. In the second and third trimesters of pregnancy drug prescribed only if there is clear evidence, if the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.
Dosing and Administration
Inside regardless of mealtime.
Adults and children over 12 years (with a body weight greater than 40 kg): the standard dose of 250 mg 2 times a day, 12 hours apart. Sinusitis, severe infections, including those caused by Haemophilus influenzae dose may be increased to 500 mg 2 times a day, with a 12 hour interval.
Average duration of treatment course is 7-14 days.
For patients with hepatic insufficiency, the recommended dose - 250 mg every 24 hours.
Clarithromycin xl 500mg
In patients with renal impairment (creatinine clearance less than 30 mL / min.), The recommended dose is 250 mg every 24 hours or, in more severe infections -on 250 mg 2 times a day, with a 12 hour interval.
In mycobacterial infections to 500 mg administered two times a day, with a 12 hour interval.
Disseminated infections caused by the MAC, in patients with AIDS:
The recommended dose of clarithromycin for adults and children over 12 years (with a body weight over 40 kg) - 500 mg 2 times a day, 12 hours apart.
Treatment should continue as long as there are clinical and microbiological confirmation of its usefulness. Clarithromycin should be used in combination with other antimicrobial agents.
Clarithromycin xl 500mg
For prevention of infections caused by MAC:
The recommended dose of clarithromycin for adults and children over 12 years (with a body weight over 40 kg) - 500 mg 2 times a day, 12 hours apart.
In odontogenic infections clarithromycin dose is 250 mg 2 times a day for 5 days.
For the eradication of H. pylori
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