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Comparative analysis of ibuprofen with other representatives of NSAIDs.
Indomethacin has a pronounced anti-inflammatory action. Ibuprofen more - analgesic effect. From this it follows that drugs such as indomethacin, may be preferred in acute inflammation (e.g. gout), while drugs such as ibuprofen are usually used for effective analgesia.
Special studies have shown that ibuprofen, unlike indomethacin, does not cause noticeable degradation in the cartilage condition by experimental and clinical data.
Aspirin has an average severity of the anti-inflammatory action, giving ibuprofen, but more pronounced in her antipyretic effect.
Ibuprofen has the smallest among all gastrotoxicity nonselective NSAIDs, rheumatologists therefore continue to use it as a drug "first attempt", especially in patients with gastric disease or as an alternative, in cases of gastrointestinal complications from the use of other nonsteroidal anti-inflammatory drugs.
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The mechanism of action of ibuprofen
The mechanism of action of ibuprofen is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in causing inflammation, pain and fever. Analgesic effect is due to a decrease in intensity of inflammation, decreasing production of bradykinin and its algogenov.
Buy ibuprofen 800 mg
The decrease in excitability teploreguliruyuschih intermediate centers of the brain results in an antipyretic action. In primary dysmenorrhea reduce intrauterine pressure and the frequency of uterine contractions. It has anti-pyretic effect, the severity of which depends on the initial body temperature and dose. Reversibly inhibits platelet aggregation. There is evidence of the stimulating effect of ibuprofen on the formation of endogenous interferon and its ability to exert immunomodulatory effects and to improve the rate of non-specific resistance of the organism.
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