| The use of Imodium
Imodium - it antidiarrheal drug which is prescribed for chronic or acute diarrhea (diarrhea). The active ingredient of the drug is loperamide, which reduces intestinal motility and reduces the urge of defecation and fecal incontinence by increasing the tone of the anal sphincter. Imodium is also used in ileostomy (breeding of the small intestine to the abdominal wall) for the regulation of the chair. It produced the drug in the form of lozenges and capsules. The starting dose for adults is 2 capsules, then the drug should take 1 capsule after each liquid discharge.
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Imodium - not such a safe drug. In our country it is allowed to take 6 years in some other countries - with 12 years. And all this is due to the fact that the drug gives some complications. The active ingredient loperamide does not cure diarrhea, but merely suppress intestinal motility and delaying everything inside, including toxins. In adults it occurs partially, and in children can cause intestinal muscle paralysis and even abdominal swelling, which subsequently leads to death. To avoid these consequences, it is better for children up to 12 years do not give Imodium, and replace it with a smectite or Enterosgel.
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Imodium in the first trimester of pregnancy to take prohibited. This is not surprising, since in this period are formed all the organs and systems baby, and getting into the body of any chemicals can cause disturbances and even deformity. Guide said that in the following months of pregnancy drug to take is possible, but only under strict medical supervision. That he will assess the risks and benefits of the drug. The manufacturer points out that the study did not reveal any adverse effects on the fetus, and it does not cause mutations in genes of the child and is not dangerous poisonous substance. Watch your diet and the state, so you do not have to risk the health of your baby!
Content of the site: Dmitry N.
Imodium: the original instructions for use
Name: Imodium (Imodium) Pharmacological
act:
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Imodium - a potent antidiarrheal drug long-acting. Loperamide hydrochloride binds to opioid receptors in the intestinal wall. Consequently inhibited acetylcholine release of prostaglandins and thus decreases propulsive motility and increases the time passing through the bowel content and the ability of the gut wall to fluid absorption. Loperamide hydrochloride increases the tone of the anal sphincter, helping to reduce fecal incontinence and urge to defecate.
Loperamide is highly specific for the substance of the intestinal wall, reaches the systemic circulation to a limited extent and practically does not penetrate the blood-brain barrier. Central action threshold much higher than the dose that exhibits the maximum effect against diarrhea.
Pharmacokinetics.
Absorption: most loperamide, ingested, absorbed in the intestine, but as a result of the intensive first-pass metabolism systemic bioavailability of approximately 0.3%.
It consists of the results of studies on the distribution of loperamide in rats show high affinity with respect to the intestinal wall with preferential binding to the receptors of the longitudinal muscle layer of the shell. Preclinical data showed that loperamide is a substrate for P-glycoprotein.
Metabolism: loperamide almost completely extracted liver. Loperamide mainly metabolized by the liver and conjugated and excreted in the bile. Oxidative N-demethylation is the principal pathway loperamide, this process is mediated mainly isomorphic CYP 3A4 and CYP 2C8. Because of the very intense effect of the first passage through the liver unchanged concentration in blood plasma drug remains very low.
Elliminatsiya:. T½ loperamide in humans is about 11 hours with a range of 9-14 h excretion of unchanged loperamide and its metabolites occurs mainly in the faeces.
The population of pediatric patients: a population pharmacokinetic studies pediatric patients have not been conducted. It is expected that the pharmacokinetic behavior of the interaction of loperamide and loperamide with drugs would be similar to those observed in adults.
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