| Individual hypersensitivity to the drug.
The drug is not prescribed to patients with these diseases:
- Acute dysentery (especially if blood clots are present in the faeces and the patient has fever);
- Severe ulcerative colitis;
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- Pseudomembranous colitis that is caused by taking antibiotics;
- Bacterial enterocolitis;
- Paralytic ileus and other diseases associated with impaired gut motility;
- Constipation;
- The drug is not indicated for patients with lactose intolerance.
Children under 6 years of drug administered under strict medical supervision. The drug is not administered in the period of lactation.
Imodium prescribed with caution during pregnancy, and patients with impaired hepatic function.
Since the drug can cause drowsiness, the period of treatment with loperamide is not recommended to perform work related to the use of potentially hazardous machinery.
Interaction
other drug
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Reported cases of interaction with drugs having similar pharmacological properties. Medications that have a depressing effect on the central nervous system, should not be used concurrently with loperamide hydrochloride in children.
Preclinical data indicate that loperamide is a substrate for P-glycoprotein. Simultaneous administration of loperamide (16 mg dose) together with the P-glycoprotein inhibitors (quinidine, ritonavir) led to an increase in loperamide plasma levels 2-3. The clinical relevance of this pharmacokinetic interaction when used in recommended doses of loperamide is unknown.
The simultaneous use of loperamide (4 mg dose) and itraconazole, an inhibitor of CYP 3A4 and P-glycoprotein, resulted in a 3-4 fold increase in loperamide plasma concentrations. In the same study, an inhibitor of CYP 2C8 gemfibrozil content of loperamide increased approximately 2-fold. Combined use of itraconazole and gemfibrozil resulted in a 4-fold increase in the maximum content Loperamide plasma and 13-fold increase in the total exposure of blood plasma. This increase is not associated with effects on the central nervous system was determined by psychomotor tests (ie, subjective drowsiness and the test for the replacement of the digital characters).
The simultaneous use of loperamide (16 mg dose) and ketoconazole, an inhibitor of CYP 3A4 and P-glycoprotein leading to 5-fold increase in loperamide plasma concentrations. This increase is not associated with increased expression of pharmacodynamic effects, as determined by pupillometry.
Concomitant treatment with desmopressin oral led to 3-fold increase in the concentration of desmopressin in plasma, presumably due to slower gastrointestinal motility. Buy loperamide hydrochloride 2mg
It is expected that drugs with the same pharmacological properties may exacerbate the effects of loperamide, and medicaments to accelerate GI transit of food may decrease the intensity of its action.
Pregnancy:
Do not take this drug during pregnancy. In this regard, pregnant and breastfeeding should be advised to consult a doctor for proper treatment.
Overdose:
Symptoms. In case of overdose (including relative overdose due to hepatic dysfunction), CNS depression may occur (stupor, loss of coordination, drowsiness, cramps, muscle hypertonicity, respiratory depression), urinary retention and the complex of symptoms such as intestinal obstruction. Children may be more sensitive to the effects on the CNS.
Treatment. If you have symptoms of an overdose, as an antidote naloxone may be used. Since the duration of action of Imodium more than naloxone (1-3 hours), you may need re-use of naloxone. To detect possible CNS depression the patient should be monitored closely for at least 48 hours.
Product form:
Capsules for 6 or 20 pieces in blister, 1 blister is in a carton box.
Storage conditions:
The drug should be stored out of reach of children at a temperature of 15 ° to 30 ° C.Buy loperamide hydrochloride 2mg
Shelf life - 3 years.
The drug is approved for use as a means of OTC.
Composition:
Chewable tablets are white, round, flat, engraved with "IMO" on one side, with the smell of vanilla and mint.
1 tablet contains:
- Loperamide hydrochloride 2 mg
- Simethicone 125 mg
Excipients: sucrose, microcrystalline cellulose, polymethacrylate, cellulose acetate, sorbitol, dextrates (hydrated), vanilla-mint flavor (natural and synthetic), sodium saccharinate, stearic acid, dicalcium phosphate.
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