| Pharmacological properties:
Pharmacodynamics. Imodium - a potent antidiarrheal drug long-acting. Loperamide hydrochloride binds to opioid receptors in the intestinal wall. Consequently inhibited acetylcholine release of prostaglandins and thus decreases propulsive motility and increases the time passing through the bowel content and the ability of the gut wall to fluid absorption.
Imodium Canada
Loperamide hydrochloride increases the tone of the anal sphincter, promoting better retention of feces and reduce the urge to defekatsii.Loperamid is highly specific for the substance of the intestinal wall, reaches the systemic circulation to a limited extent and practically does not penetrate the blood-brain barrier. central action threshold is much higher than the dose that provides maximum effect with respect diarei.Farmakokinetika. loperamide hydrochloride is readily adsorbed in the intestine, but is almost completely extracted and metabolised by the liver, which is conjugated and excreted in the bile. T? Imodium a person on average - 11 h (9-14 h). Elimination occurs by oxidative N-demethylation, which is the main metabolic changes by loperamide. Binding to plasma proteins - 95%, mainly to albumin. Write mainly faeces.
Indications for use:
Symptomatic treatment of acute and chronic diarrhea. Imodium can be recommended in case of traveler's diarrhea (traveler). If there is sufficient evidence that the period of treatment - 2 days. Only in the case of the use of blood in the stool should be delayed to determine the cause of this phenomenon.
Mode of application:
Imodium is not intended for the initial treatment of severe diarrhea, which is accompanied by dehydration and reduction of the level of electrolytes. In particular, in children, it is desirable to compensate for the loss due to hormone therapy or parenterally peroralno.Vzroslye and children older than 6 letOstraya diarrhea: starting dose for adults is 2 capsules (4 mg) for children - 1 capsule (2 mg); subsequently 1 capsule after each bowel movement konsistentsii.Hronicheskaya liquid diarrhea: starting dose for adults - 2 capsules (4 mg) for children - 1 capsule (2 mg) daily; Further, this dose is chosen in such a way that solid feces frequency was 1-2 times per day, the dosage is reached 1-6 capsules (2-12 mg) ezhednevno.Maksimalnaya daily dose for adults with chronic and acute diarrhea - 8 capsules (16 mg of ) for children - should be calculated on the basis of body weight - 3 capsules per 20 kg weight tela.
Imodium Canada
Pri acute diarrhea, if within 48 hours of clinical improvement is not observed, taking Imodium should prekratit.Primenenie for the treatment of elderly patients with ascending correction is required dose for elderly patients vozrasta.Primenenie with impaired renal function does not require dosage adjustment in patients with impaired function pochek.
Imodium Canada
Primenenie in violation of the functions pecheniHotya pharmacokinetic data on the effect of the drug in patients with hepatic impairment are not available, such patients Imodium should be used with caution due to slowing metabolism first pass (see. SPECIAL INSTRUCTIONS).
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