| Effects on ability to drive a car or operating machinery
Because of the potential for adverse effects on the central nervous system must be cautious when driving or other mechanisms.Biaxin xl
Interaction with other medicinal products and other forms of interaction
As the appointment of other antibiotics macrolide number of patients who are also receiving drugs that are metabolized by cytochrome P450 (CYP3A: alprozolam, astemizole, carbamazepine, tsylotazol, cisapride, methylprednisolone, omeprazole, pimozide, quinidine, sildenafil, simvastatin, tacrolimus, terfenadine, vinblastine , warfarin, ergot alkaloids, triazoles, midazolam, dyzopiramid, lovastatin, rifabutin, cyclosporine, and other systems P450 isoenzymes, phenytoin, theophylline, valproate), the use of clarithromycin-Kredofarm can increase levels of these drugs in the blood serum. Concomitant administration of clarithromycin-Kredofarm and inhibitors of HMG-CoA reductase, such as lovastatin or simvastatin, is rarely observed rhabdomyolysis.Biaxin xl
Concomitant use of clarithromycin-Kredofarm of cisapride, pimozide may lead to QT-interval prolongation and cardiac arrhythmias.
The metabolism of terfenadine, astemizole changes while applying it with clarithromycin-Kredofarm that sometimes lead to cardiac arrhythmia.
Clarithromycin-Kredofarm while the application of theophylline or carbamazepine may cause increase their levels in serum and increasing their toxicity.
Concomitant administration of clarithromycin, quinidine or Kredofarm of observed cases dyzopiramidom flicker / ventricular fibrillation. It takes control of these drugs in the blood during treatment with clarithromycin-Kredofarm.Biaxin xl
The use of clarithromycin-Kredofarm patients taking warfarin or digoxin may lead to the strengthening of action by reducing the excretion level. Therefore, patients taking warfarin need to control the size of prothrombin time. It is also necessary to control the level of digoxin in the blood serum.
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