Clarithromycin 500 mg price
| Clarithromycin 500 mg price
Concomitant use of clarithromycin immediate release tablets and zidovudine in HIV-infected patients may cause decrease zidovudine equilibrium concentrations in serum. Because clarithromycin able to prevent absorption of oral zidovudine while taking should follow the 4-hour interval between doses of clarithromycin and zidovudine. On such cooperation in the application of the suspension of clarithromycin and zidovudine or dydeoksynazynu in children have been reported.
Phenytoin and valproate
There have been spontaneous or published reports of interactions CYP3A inhibitors, including clarithromycin with drugs that are not deemed to be metabolized by CYP3A (eg phenytoin and valproate). It is recommended to determine the levels of these drugs in serum while appointing them with clarithromycin. Reported increase their levels in serum.
Clarithromycin 500 mg price
The use of clarithromycin (500 mg two times daily) with atazanavir (400 mg 1 time per day), which are substrates and inhibitors of CYP3A, leading to an increase in exposure of clarithromycin 2 times and reducing exposure 14-OH-clarithromycin by 70% with an increase in AUC atazanavir is 28%. Because clarithromycin has great therapeutic range, there is no need for dose reduction in patients with normal renal function. Clarithromycin dose should be reduced by 50% for patients with creatinine clearance 30-60 ml / min and 75% for patients with a creatinine clearance <30 ml / min. Doses of clarithromycin, higher than 1000 mg per day should not be used in conjunction with protease inhibitors.
Clarithromycin 500 mg price
Because of the risk of hypotension should be used with caution clarithromycin simultaneously with calcium channel blockers that are metabolized by CYP3A4 (eg, verapamil, amlodipine, diltiazem). The interaction may increase plasma concentrations of clarithromycin as well as calcium channel blockers. In patients treated with clarithromycin and verapamil, experienced hypotension, bradiarytmiyi and lactic acidosis.
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| Категория: clarithromycin buy online | Добавил: Dnister (21.11.2016)
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