| pharmachologic effect
Cialis - a drug containing tadalafil. The active drug component reversibly selectively inhibits cyclic guanosine monophosphate (cGMP) - specific phosphodiesterase type 5 (PDE 5). Cialis alcohol
During sexual stimulation marked local release of nitric oxide, while specific inhibition of the activity of phosphodiesterase type 5 leads to increased levels of cGMP in the corpus cavernosum. Under the effect of tadalafil there is a decrease in smooth muscle tone and increase blood flow to the tissues of the penis, which helps to improve erection. Tadalafil has no sexual stimulation.
Action tadalafil other phosphodiesterase slightly Cialis therefore has no effect on the cardiovascular system, liver function, skeletal muscle and other organs. Tadalafil does not change the qualitative characteristics of sperm, does not cause changes in testosterone, FSH and LH in the blood.
The effect of Cialis only develops on condition of sexual stimulation. Starting tadalafil therapeutic effect begins 15 minutes after administration. Cialis acts within 36 hours after oral administration.
Cialis alcohol
The active ingredient of Cialis is well absorbed after oral administration. Peak plasma concentration of tadalafil is achieved within 2 hours after ingestion. Absorption rate and bioavailability of tadalafil is independent of food intake.
Cialis alcohol
Order tadalafil 94% bound to plasma proteins. Metabolized active ingredient of Cialis, with the participation of the enzyme CYP3 A4. Tadalafil is excreted predominantly in the form of metabolites kidneys and intestines, it reaches a half-life of 17.5 hours.
|